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While Metformin remains the most frequently initiated treatment, this analysis reveals a nuanced picture in which its role may be evolving rather than ending, requiring a reassessment of its position in contemporary diabetes care algorithms

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The C677T variant results from a single nucleotide substitution at this position, in which cytosine is replaced by thymine resulting a conversion of alanine to valine residue 24

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Participants also incorporated an improved diet and exercise during the trial

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van Eijk, R

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